Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets |
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| Authors: | Liu Jiyun Zhang Zhongsheng Tan Xiaojian Hol Wim G J Verlinde Christophe L M J Fan Erkang |
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| Institution: | Biomolecular Structure Center, Department of Chemistry, University of Washington, Seattle, Washington 98195, USA. |
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| Abstract: | Structure-based design of a bifunctional ligand for two protein pentamers, cholera toxin B pentamer (CTB) and human serum amyloid P component (SAP), leads to multivalent dimerization of CTB and SAP in solution. This multivalent heterodimerization of proteins significantly enhances the affinity of the bifunctional ligand toward both target proteins. |
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