Biodistribution of the bone imaging agents99mTc-DHPE and99mTc-MDP in rats

The self life of the freeze-dried formulation kits utilized for the preparation of the new bone imaging radiopharmaceutical^99mTc-1,2-dihydroxy-1,2-bis/dihydroxyphosphinyl/ethane /^99mTc-DHPE/ has been investigated as well as the toxicity of the DHPE. In a biodistribution investigation of^99mTc-DHPE in rats, in comparison to^99mTc-methylenediphosphanate /^99mTc-MDP/,^99mTc-DHPE exhibited a certain extent higher skeleton uptake, a higher blood clearance rate, a very low concentration in other organs, a satisfactory biological stability and excretion primarily through the kidneys. These properties demonstrate that^99mTc-DHPE is a new promising skeleton imaging radio-pharmaceutical.