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Synthesis of hollow ferrite nanospheres for biomedical applications |
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| Authors: | Masaru Tada Takashi Kanemaru Takashi Nakagawa Masanori Abe |
| Affiliation: | a Department of Physical Electronics, Tokyo Institute of Technology, Meguro-ku, 2-12-1, Ookayama, Meguro, Tokyo, 152-8552, Japan b Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan |
| Abstract: | Hollow ferrite spheres of 220-340 nm diameter were synthesized at 60 °C as multi-functionalized magnetic carriers which are potentially applicable both as drug delivery systems (DDS) and hyperthermia treatment. We found that SH and OH groups on the silica template spheres enabled the fabrication of continuous ferrite shells of 20-30 nm in thickness. Transmission electron microscopy and energy-dispersive spectroscopy revealed that the templates were dissolved by a NaOH solution, yielding hollow particles exhibiting saturation magnetization of 78 emu/g. The results suggested that the ferrite shells are porous and the pores work as pathway for releasing drugs from the hollow particle inside. |
| Keywords: | Hollow sphere Spinel ferrite Drug delivery carrier Aqueous solution synthesis Ferrite plating |
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