An ultrasensitive electrochemical DNA sensor based on the ssDNA-assisted cascade of hybridization reaction |
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| Authors: | Yin Bin-Cheng Guan Yi-Meng Ye Bang-Ce |
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| Affiliation: | Lab of Biosystem and Microanalysis, East China University of Science & Technology, Shanghai 200237, P.R. China. |
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| Abstract: | We have developed a simple and ultrasensitive E-DNA sensor based on the ssDNA-assisted cascade of a hybridization reaction mechanism to form a long concatamers structure to improve its sensitivity, significantly. The proposed sensor was applied to sequence-specific DNA and ATP detection. Experimental results showed a quantitative measurement with the detection limit as low as 1 aM for specific DNA and 10 fM for ATP. |
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