Formal Total Synthesis of (+)‐Cortistatins A and J |
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| Authors: | Prof. Dr. Pauline Chiu |
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| Affiliation: | Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (P. R. China) |
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| Abstract: | ![]()
An efficient formal total synthesis of (+) cortistatins A and J has been accomplished, by exploiting a highly diastereoselective intramolecular [4+3] cycloaddition of epoxy enolsilanes as the key reaction to construct rings B and C of the cortistatins in one step. |
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| Keywords: | alkaloids [4+3] cycloaddition cortistatins natural products total synthesis |
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