Cationic Cobalt(III)‐Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives |
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| Authors: | Yujie Liang Yu‐Feng Liang Conghui Tang Yizhi Yuan Prof. Dr. Ning Jiao |
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| Affiliation: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (P. R. China), Fax: (+86)?10‐82805297 http://sklnbd.bjmu.edu.cn/nj/;2. State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (P. R. China) |
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| Abstract: | ![]()
A cationic cobalt(III)‐catalyzed direct C?H amidation of unactivated (hetero)arenes and alkenes by using 1,4,2‐dioxazol‐5‐ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant‐free conditions with a broad substrate scope. Moreover, 6‐arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, and anti‐HCV activities, can be smoothly amidated, thus offering a mild protocol for their late stage functionalization. |
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| Keywords: | amidation C H functionalization C N bond formation cobalt purine compounds |
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