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Regioselective remote C |
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| Authors: | Clément Ghiazza Moussa Ndiaye Anfal Hamdi Anis Tlili Thierry Billard |
| Affiliation: | 1. Institute of Chemistry and Biochemistry (ICBMS – UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622 Villeurbanne, France;2. CERMEP-In vivo imaging, Groupement Hospitalier Est, 59 Bd Pinel, 69003 Lyon, France |
| Abstract: | Herein, the direct C-5 fluoroalkylselenolation of 8-aminoquinolines is described. The Pd-catalyzed reaction is performed with the in situ generated fluoroalkylselenyl chloride and various 8-aminoquinoline amides or sulfonamides. The desired products were formed in moderate to excellent yields. |
| Keywords: | Trifluoromethylselenolation Trifluoromethylselenyl chloride Aminoquinoline Fluorinated compounds Radical reaction |
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