Synthesis of 5‐phenyl‐5,6,7,8‐tetrahydro‐1,6‐naphthyridines and 5‐phenyl‐6,7,8,9‐tetrahydro‐5H‐pyrido[3,2‐c]azepines as potential D1 receptor ligands

A new access to 5‐phenyl‐5,6,7,8‐tetrahydro‐1,6‐naphthyridines 25a‐28a (n=1) and 5‐phenyl‐6,7,8,9‐tetrahydro‐5H‐pyrido3,2‐c]azepines 25b‐28b (n=2) has been developed by first preparing the functional pyridine moiety followed by intramolecular cyclization forming the partially reduced ring.