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One-pot catalytic enantioselective domino nitro-michael/michael synthesis of cyclopentanes with four stereocenters |
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| Authors: | Zhao Gui-Ling Ibrahem Ismail Dziedzic Pawel Sun Junliang Bonneau Charlotte Córdova Armando |
| Affiliation: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden. |
| Abstract: | A highly enantioselective organocatalytic one-pot synthesis of nitro-, formyl-, and ester-functionalized cyclopentanes with four stereocenters is presented. The cyclopentanes were formed as a predominant diasteroisomer and isolated in high yields with 97-99 % ee. |
| Keywords: | aldehydes asymmetric catalysis conjugate additions cyclopentanes domino reactions organocatalysis |
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