| Synthetic Studies of an Analogue of HIV-1 Protease Inhibitors of Didemnaketals:Construction of the C1-C8 Intermediate |
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| 作者姓名： | Ping Zhen WANG Yan Xing JIA Yong Qiang TU Bin WU |
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| 作者单位： | Department of Chemistry. National Laboratory of Applied Organic Chemistry，Lanzhou University.Lanzhou 730000 |
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| 摘 要： | ThedidenlnaketalsAandBhaveprovedtobesignificantinhibitorstoHIV-Iprotease'.UPtotilepresent.however,nosuccessfulsynthesishasbeenreported.Inconnectiollx'l,lthOLlrs}'ntheticstudiesoftheiranalogLles,wehavereportedasuccesslillsynthesisofthesimilarilltermediateof32.Hereinwewouldpresentanefficientprocedureforthediastereoselectivesynthesisofanotherintermediate4.Basedoiltileretrosyntheticanalysis,theintermediate4couldbesynthesizedfromllaturalI.-(-)-nlelltllollebecauseofthevaltlablechiralCSmethyl.…
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Synthetic Studies of an Analogue of HIV-1 Protease Inhibitors of Didemnaketals:Construction of the C1-C8 Intermediate |
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| Ping Zhen WANG, Yan Xing JIA, Yong Qiang TU, Bin WU.Synthetic Studies of an Analogue of HIV-1 Protease Inhibitors of Didemnaketals:Construction of the C1-C8 Intermediate[J].Chinese Chemical Letters,1999(9). |
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| Authors: | Ping Zhen WANG Yan Xing JIA Yong Qiang TU Bin WU |
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| Abstract: | A convenient and stereoseleetive approach to the synthesis of (3S. 4R. 6S)-2-oxo-3.4- dihydroxy-6-methyl-octanate derivative,a key intermediate for the synthesis of IIIV-1 proteaseinhibitor of didemnaketals analogue,has been developed successfully from L-(-)-menthone. |
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| Keywords: | Didemnaketals 2-oxo-3 4-dihydroxy-6-methyl-octanate steroselective synthesis |
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