Aminolysis reaction of calix [ 4 ] arene esters and crystal structures and conformational behaviors of calix[4]arene amides

We first make use of aminolysis of calix4]arene esters to synthesize calix4]arene amides. When the two ethyl esters of the calix4]arene esters are aminolysized, the 1, 3‐amide derivative is formed selectively. The crystal structures of the calix‐4] arene with two butyl amide (3b) and four butyl amide moieties (4b) were determined. The intermolecular hydrogen bonds make 4b form two‐dimensional net work insolid state. The ¹H NMR spectra prove mat 3b is of a pinched cone conformation, while 4b and tetraheptylamide‐calix4]arene (6b) take fast interconversion between two C_2r isomers in solution and appear an apparent cone conformation at room temperature. As decreasing temperature, the interconversion rate decreases gradually and, finally, the interconversion process is frozen at T_c = ?10°C, which makes both conformations of 4b and 6b the pinched cone structures. The hydrogen bond improves the interconversion barrier, and the large different values of the potential barrier between 6b and 4b (or 6b) may be of forming different hydrogen bonds.