Metal-free cascade boron-heteroatom addition and alkylation with diazo compounds |
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Authors: | Jiahang Lv Binlin Zhao Ying Han Yu Yuan Zhuangzhi Shi |
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Institution: | 1. College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China;2. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China;3. Department of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing 210037, China |
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Abstract: | Transition metal-catalyzed carbene transfer reaction is one of the most notable advances for C?C bond formation reactionsduring the past decade, which has been widely employed in the preparation of C3-substituted indoles. Here, we described an efficient example of catalyst- and metal-free aminoboration of alkynes and CC bond formation with diazo compounds to produce C3-substituted indoles. Diverse alkynylanilines and diazo compounds can be utilized for this tandem transformation under mild reaction conditions, resulting in broad functional group compatibility. Additionally, this metal-free strategy can be extended to construct substituted benzofurans. |
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Keywords: | Indoles Aminoboration Metal-free Diazo compounds |
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