Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis |
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Authors: | Yoshikawa Masayuki Morikawa Toshio Kobayashi Hisanori Nakamura Akihiko Matsuhira Koudai Nakamura Seikou Matsuda Hisashi |
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Institution: | Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan. myoshika@mb.kyoto-phu.ac.jp |
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Abstract: | The methanolic extract from the fruit of Citrullus colocynthis showed an inhibitory effect on ear passive cutaneous anaphylaxis reactions as a type I allergic model in mice. From the methanolic extract, two new cucurbitane-type triterpene glycosides, colocynthosides A and B, were isolated together with 17 known constituents. The structures of colocynthosides A and B were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal cucurbitane-type triterpene glycoside, cucurbitacin E 2-O-beta-D-glucopyranoside, and its aglycon, cucurbitacin E, exhibited the antiallergic activity at a dose of 100 and 1.25 mg/kg, p.o., respectively. |
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