A walk around the A3-coupling |
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Authors: | Peshkov Vsevolod A Pereshivko Olga P Van der Eycken Erik V |
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Institution: | Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium. |
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Abstract: | In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A(3)-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A(3)-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A(3)-coupling as well as different tandem reactions involving A(3)-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A(3)-couplings and related transformations. |
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