Flow Injection Determination of Lomefloxacin Based on Photochemically Sensitized Chemiluminescence |
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Authors: | Chunyan Sun Ning Lian Huichun Zhao Lin Yi Linpei Jin |
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Institution: | (1) Department of Chemistry, Beijing Normal University, 100875 Beijing, P.R. China |
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Abstract: | A photochemical chemiluminescence (CL) method for the determination of lomefloxacin (LFX) is proposed. LFX undergoes a photochemical reaction when irradiated with ultraviolet light, and a complex is formed when the photoproduct reacts with terbium(III), which can greatly enhance the CL of the Ce4+–Na2SO3 system. Under optimum experimental conditions, the linear range is between 9.0×10–10 and 1.0×10–5M, and the detection limit is 2.2×10–10M. The relative standard deviation for the determination of 5.0×10–8M LFX was 3.0% (n=11). The method has been successfully applied to the determination of LFX in dosage form, serum samples and urine samples. The recoveries were 97.9–102.3% for serum and urine samples. The possible mechanism is presented. |
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Keywords: | : Photochemical chemiluminescence lomefloxacin terbium(III) |
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