Derivatives of the closo-dodecaborate anion and their application in medicine |
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| Authors: | Sivaev I B Bregadze V I Kuznetsov N T |
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| Institution: | (1) Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds, 28 ul. Vavilova, 119991 Moscow, Russian Federation;(2) Russian Academy of Sciences, N. S. Kurnakov Institute of General and Inorganic Chemistry, 31 Leninsky prosp., 119991 Moscow, Russian Federation |
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| Abstract: | The paper presents a comparative analysis of the possibilities and characteristic features of the application of various polyhedral boron compounds, viz., the closo-decaborate anion B10H10]2–, the closo-dodecaborate anion B12H12]2–, the carba-closo-dodecaborate anion CB11H12]–, carboranes C2B10H12, and the bis(dicarbollide) complexes M(C2B9H11)2]– (M = Fe, Co, or Ni), in boron neutron capture therapy (BNCT) for cancer. The requirements on compounds used in BNCT are formulated and the advantages of the application of the closo-dodecaborate anion are considered. The data on the synthesis of various derivatives of the closo-dodecaborate anion, which either already found use in BNCT or are most promising in this field, are summarized. The possibilities of the application of agents derived from the closo-dodecaborate anion in medical diagnostics are discussed. |
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| Keywords: | closo-dodecaborate anion application boron neutron capture therapy for cancer radioisotope diagnostics X-ray imaging diagnostics |
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