Identification of inhibitors for UDP-galactopyranose mutase |
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| Authors: | Soltero-Higgin Michelle Carlson Erin E Phillips John H Kiessling Laura L |
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| Affiliation: | Departments of Biochemistry and Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. |
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| Abstract: | The flavoenzyme uridine 5'-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16 000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified. |
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