Effect of oxalate test dose size on absolute and percent oxalate absorption |
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Authors: | Gerd E Von Unruh Alexandra E Bell Albrecht Hesse |
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Institution: | 1. Department of Internal Medicine I , University of Bonn , Sigmund-Freud-Str. 25, 53105, Bonn, Germany gerd.von_unruh@ukb.uni-bonn.de;3. Department of Urology, Division of Experimental Urology , University of Bonn , Sigmund-Freud-Str. 25, 53105, Bonn, Germany |
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Abstract: | The purpose of this pilot study was to establish the dependence or independence of oxalate absorption on the quantity of the test dose of sodium oxalate over a range of test doses corresponding to physiological dietary oxalate intake values. Gastrointestinal oxalate absorption was measured with the 13C2]oxalate absorption test. Six healthy volunteers were always tested under standardized dietary conditions with 63 mg dietary oxalate and 800 mg dietary calcium per day. The volunteers were tested thrice each with sodium oxalate test doses of 25, 50, 200, and 600 mg. Additionally, 1000 mg sodium oxalate was applied once to three of these volunteers. The oxalate absorption of the six volunteers tested under the standardized conditions with 50 mg sodium 13C2]oxalate was 7.2 ± 2.62 % (mean ± SD), similar to the 120 volunteers tested previously: 8.0 ± 4.4 % (mean ± SD). The tests with sodium 13C2]oxalate doses in the range 25–1000 mg revealed similar percent oxalate absorption values. In conclusion, in healthy volunteers, the amount of oxalate absorbed in the gastrointestinal tract increased proportionally with the higher test doses of oxalate. However, percent oxalate absorption remained unchanged with test doses in the dose range of physiological dietary oxalate intakes. |
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Keywords: | Absorption test [13C2]oxalate Calcium oxalate Carbon-13 Men Oxalate dose Urine |
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