| An in vitro Study on Transition from NO-Hemoglobin to Methemoglobin： Oxygen Effect |
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| 引用本文： | 马炯 岑剡 陈暨耀. An in vitro Study on Transition from NO-Hemoglobin to Methemoglobin： Oxygen Effect[J]. 中国化学, 2005, 23(5): 637-639. DOI: 10.1002/cjoc.200590637 |
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| 作者姓名： | 马炯 岑剡 陈暨耀 |
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| 作者单位： | [1]DepartmentofPhysics,FudanUniversity,Shanghai200433,China／／StateKeyLaboratoryofAppliedSurfacePhysics,FudanUniversity,Shanghai200433,China [2]DepartmentofPhysics,FudanUniversity,Shanghai200433,China／／StateKeyLaboratoryforAdvancedPhotonicMaterialsandDevices,FudanUniversity,Shanghai200433,China |
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| 摘 要： | The nitrosyl-hemoglobin (HbNO) is the carrier of nitric oxide (NO) which is the important messenger molecule displaying multiple physiologic and pathophysiologic roles. However it is still not clear for the fate of HbNO molecules during the venous-arterial transit. In this letter, the HbNO transition in vitro was studied by using the electron paramagnetic resonance (EPR) spectra. It was found that HbNO molecules were stable when oxygen did not exist in the system but not stable in aerobic conditions. The absorption spectra further revealed that the methemoglobin (metHb) was the product of HbNO in aerobic environment, showing that the HbNO changed to metHb when there were enough oxygen molecules in the system.
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| 关 键 词： | 正铁血红蛋白 血色素 氧气 氮氧化物 分子结构 |
An in vitro Study on Transition from NO‐Hemoglobin to Methemoglobin: Oxygen Effect |
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| Ma Jiong,Cen Yan,Chen Ji‐Yao. An in vitro Study on Transition from NO‐Hemoglobin to Methemoglobin: Oxygen Effect[J]. Chinese Journal of Chemistry, 2005, 23(5): 637-639. DOI: 10.1002/cjoc.200590637 |
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| Authors: | Ma Jiong Cen Yan Chen Ji‐Yao |
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| Abstract: | The nitrosyl‐hemoglobin (HbNO) is the carrier of nitric oxide (NO) which is the important messenger molecule displaying multiple physiologic and pathophysiologic roles. However it is still not clear for the fate of HbNO molecules during the venous‐arterial transit. In this letter, the HbNO transition in vitro was studied by using the electron paramagnetic resonance (EPR) spectra. It was found that HbNO molecules were stable when oxygen did not exist in the system but not stable in aerobic conditions. The absorption spectra further revealed that the methemoglobin (metHb) was the product of HbNO in aerobic environment, showing that the HbNO changed to metHb when there were enough oxygen molecules in the system. |
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| Keywords: | nitric oxide (NO) hemoglobin methemoglobin |
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