Effect of the Orientation of Amide Linkage Groups on the Enantioselectivity of Two Related Synthetic Polymeric Chiral Stationary Phases |
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| Authors: | Xinxin Han Jeffrey W Remsburg Lingfeng He Thomas E Beesly Daniel W Armstrong |
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| Institution: | (1) Chemistry and Biochemistry Department, The University of Texas at Arlington, Arlington, TX 76019, USA;(2) Advanced Separation Technologies Inc, 37 Lesile Court, P. O. Box 297, Whippany, NJ 07981, USA |
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| Abstract: | Two new synthetic polymeric chiral stationary phases (CSPs) based on trans-(1S,2S)-cyclohexanedicarboxylic acid bis-4-vinylphenylamide (I) and trans-N,N′-(1R,2R)-cyclohexanediyl-bis-4-ethenylbenzamide (II) monomers were prepared and evaluated by normal phase high performance
liquid chromatography (HPLC) and supercritical fluid chromatography (SFC). A variety of chiral compounds were separated on
these two new CSPs. The different orientation of the amide groups in the two CSPs resulted in a striking difference in the
enantioselectivity properties of these two CSPs. Their differences in enantioselectivity with HPLC and SFC were compared. |
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| Keywords: | Column liquid chromatography Supercritical fluid chromatography Polymeric chiral stationary phases Enantioselectivity Enantiomers |
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