| 新型N-取代酰基-N-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺的合成 |
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| 引用本文： | 李慧,章文军,梁莉.新型N-取代酰基-N-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺的合成[J].合成化学,2011,19(5):645-647. |
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| 作者姓名： | 李慧 章文军 梁莉 |
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| 作者单位： | 河北工业大学化工学院,天津,300130 |
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| 基金项目： | 河北省自然科学基金资助项目(B2005000007) |
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| 摘 要： | 为了得到具有更好抗抑郁活性的新型化合物,抗抑郁药度洛西汀通过N-酰化反应或N-烷基化反应与取代酰氯拼合,制得5个新型N-取代酰基-N-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺,其结构经1H NMR,IR和MS表征.
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| 关 键 词： | 抗抑郁药 度洛西汀 丙胺 N-酰化 药物合成 |
Synthesis of Novel N-substituted-acyl-N-methyl-3-(naphthalene-1-yloxy)-3-(2-thienyl)propanamine Derivatives |
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| LI hui,ZHANG Wen-jun,LIANG Li.Synthesis of Novel N-substituted-acyl-N-methyl-3-(naphthalene-1-yloxy)-3-(2-thienyl)propanamine Derivatives[J].Chinese Journal of Synthetic Chemistry,2011,19(5):645-647. |
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| Authors: | LI hui ZHANG Wen-jun LIANG Li |
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| Institution: | LI hui,ZHANG Wen-jun,LIANG Li(School of Chemical Engineering and Technology,Hebei University of Technology,Tianjin 300130,China) |
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| Abstract: | In order to prepare novel compound of more antidepressant effect,an antidepressant duloxetine was pieced together with substituted acyl chloride by N-acylation and N-alkylation,respectively to synthesiz five novel N-substituted-acyl-N-methyl-3-(naphthalene-1-yloxy)-3-(2-thienyl)propanamines.The structures were characterized by 1H NMR,IR and MS. |
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| Keywords: | antidepressant duloxetine propanamine N-acylation drug synthesis |
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