Testing of the structure of macromolecular polymer films containing solid active pharmaceutical ingredient (API) particles |
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| Authors: | É Bölcskei K Süvegh T Marek G Regdon K Pintye-Hódi |
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| Institution: | 1. Hungarian Academy of Sciences, Centre for Energy Research, P.O. Box 49, H-1525 Budapest, Hungary;2. Laboratory for Waste Management, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland;3. Karlsruhe Institute of Technology, Institute for Synchrotron Radiation, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany |
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| Abstract: | The aim of the present study was to investigate the structure of free films of Eudragit® L 30D-55 containing different concentrations (0%, 1% or 5%) of diclofenac sodium by positron annihilation spectroscopy. The data revealed that the size of the free-volume holes and the lifetimes of ortho-positronium atoms decreased with increase of the API concentration. Films containing 5% of the API exhibited a different behavior during storage (17 °C, 65% relative humidity (RH)) in consequence of the uptake of water from the air. |
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