Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction |
| |
| Authors: | Kim Joa Kyum Kim Young Ha Nam Ho Tae Kim Bum Tae Heo Jung-Nyoung |
| |
| Affiliation: | Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, 100 Jang-dong, Daejeon 305-600, Korea. |
| |
| Abstract: | A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki-Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formylphenylboronic acid, has been developed. The approach is used to efficiently produce a number of natural aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
