| 紫外线激活氚原子—制备氚标记单磷酸阿糖腺苷的研究 |
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| 引用本文： | 骆日佑,王集民,林展江,方正,黄观祥.紫外线激活氚原子—制备氚标记单磷酸阿糖腺苷的研究[J].分析测试学报,1989(4). |
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| 作者姓名： | 骆日佑 王集民 林展江 方正 黄观祥 |
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| 作者单位： | 中国广州分析测试中心
(骆日佑，王集民，林展江)，广东省药物研究所
(方正)，广东省药物研究所(黄观祥) |
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| 摘 要： | 本文采用紫外线激活氚原子的方法,进行氚-氢同位素交换反应,制得氚标记单磷酸阿糖腺苷(9—~3H—mparaA)。产品的纯度是层析纯;放射性比活度16GBq.m mol~(-1);放射化学纯度92.0%。本法的优点是:交换反应温和、反应时间较短、不易破坏生物活性、引起的副产物少、产品分离和纯化较方便。
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| 关 键 词： | 单磷酸阿糖腺苷(mparaA) 抗癌药物 紫外线激活氚原子 |
Study on the preparation of Tritium Labelled Monophosphate 8-B-D-Arabinofuranosyl Adenine Using Tritium Activated with UV light |
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| Luo Riyou,Wang Jimin,Lin Zhanjiang,Fang Zheng,Huang Guangxian Chinese National Analytical Centre,Guangzhou Guandsg Institute of Materia Medica.Study on the preparation of Tritium Labelled Monophosphate 8-B-D-Arabinofuranosyl Adenine Using Tritium Activated with UV light[J].Journal of Instrumental Analysis,1989(4). |
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| Authors: | Luo Riyou Wang Jimin Lin Zhanjiang Fang Zheng Huang Guangxian Chinese National Analytical Centre Guangzhou Guandsg Institute of Materia Medica |
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| Abstract: | Tritium labelled monophosphate 8-B-D-arabinofuranosyl adenine was prepared by exchange reaction of tritium that is activated by UV light and hydrogen isotope. The purity of theproduct is chromatographic pure, with a radiation specific activation of 16 GBq. mmol~(-1) and aradiochemical purity of 92.0%. This method has the following advantages: involving no violentreaction, with shorter reaction time, no damaging to biological activity,with fewer by-productsand convenient to achieving separation and purifiation. |
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| Keywords: | Monophosphate 8 -B-D-arabisnofuranosyl adenine (mparaA) anticancerpharmaceu-ticals ultraviolet ray activated tritium atomes |
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