Synthesis,structure and cytotoxic activity of binuclear phenyltin(IV) complexes with N,N′‐bis(2‐hydroxybenzyl)‐1,2‐ethanebis(dithiocarbamate) ligand |
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Authors: | Laijin Tian Xiaofeng Zheng Xiaoliang Zheng Yuxi Sun Dongmei Yan Linglan Tu |
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Institution: | 1. Department of Chemistry, Qufu Normal University, Qufu 273165, China;2. Institute of Materia Medica, Zhejiang Academy of Medical Science, Hangzhou 310013, China |
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Abstract: | Two new dinuclear phenyltin(IV) complexes derived from N,N′‐bis(2‐hydroxybenzyl)‐1,2‐ethanebis(dithiocarbamate) ligand, 2‐HOC6H4CH2N(CS2SnPh3)CH2]2 ( 1 ) and 2‐HOC6H4CH2N(CS2SnClPh2)CH2]2 ( 2 ) have been synthesized and characterized by elemental analysis, IR and NMR (1H, 13C and 119Sn) spectra. The crystal structures of complexes 1 and 2 were determined by X‐ray single crystal diffraction and show that the dithiocarbamate ligand is coordinated to the tin atom in the anisobidentate manner and the tin atom is five‐coordinated. The coordination geometry of tin atom is best described as an intermediate between trigonal bipyramidal and square pyramidal with τ‐values of 0.63 and 0.53, respectively. Intermolecular hydrogen bonds (O H···S and O H···Cl) in 1 and 2 connect neighboring molecules into a one‐dimensional supramolecular chain with the centrosymmetric cyclic motifs. Complex 1 has potent in vitro cytotoxic activity against two human tumor cell lines, CoLo205 and Bcap37, while complex 2 displays weak cytotoxic activity. Copyright © 2011 John Wiley & Sons, Ltd. |
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Keywords: | organotin complex dithiocarbamate cytotoxic activity crystal structure |
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