Synthesis,spectroscopic, thermal and biological aspects of drug‐based copper(II) complexes |
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| Authors: | Paresh N. Patel Darshana J. Patel Hasmukh S. Patel |
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| Affiliation: | Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar‐388120, Gujarat, India |
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| Abstract: | A series of novel complexes of the type Cu(II)(Ln)2(H2O)2]•xH2O [where Ln = L 1–4 , these ligands being described as: L 1 , 2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)phenol, x = 1; L 2 , 2‐({4‐[6,7‐dihydrothieno[3,2‐c] pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)‐5‐(methoxy)phenol, x = 2; L 3 , 5‐chloro‐2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino}methyl)phenol, x = 2; and L 4 , 5‐bromo‐4‐chloro‐2‐({4‐[6,7‐dihydrothieno[3,2‐c]pyridin‐5(4H)‐ylsulfonyl]phenylimino} methyl)phenol, x = 1] was investigated. They were characterized by elemental analysis, IR, 1H‐NMR, 13C‐NMR and electronic spectra, magnetic measurements and thermal studies. The FAB‐mass spectrum of [Cu(II)( L 1 )2(H2O)2]•H2O was determined. A magnetic moment and reflectance spectral study revealed that an octahedral geometry could be assigned to all the prepared complexes. Ligands (Ln) and their metal complexes were screened for their in vitro antibacterial activity against Bacillus subtillis, Pseudomonas aeruginosa, Escherichia coli and Serratia marcescens bacterial strains. Kinetic parameters such as order of reaction (n), the energy of activation (Ea), the pre‐exponential factor (A), the activation entropy (ΔS≠), the activation enthalpy (ΔH≠) and the free energy of activation (ΔG≠) are reported. Copyright © 2011 John Wiley & Sons, Ltd. |
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| Keywords: | Cu(II) complexes spectroscopic Freeman‐Carroll method antibacterial activity |
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