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Synthesis of thiazolidin-4-ones via [3+2] cycloaddition of in situ generated aza-oxyallylic cations with isothiocyanates |
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| Authors: | Gangqiang Wang Sen Zhao Rongxing Chen Liangfeng Yang Jian Wang Haibing Guo Minghu Wu Justin Domena Yalan Xing Shaofa Sun |
| Affiliation: | 1. Non-power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, China;2. Department of Chemistry, William Paterson University of New Jersey, 300 Pompton Road, Wayne, NJ 07470, United States |
| Abstract: | A highly efficient one-pot synthesis of thiazolidin-4-ones via [3+2] cycloaddition of aza-oxyallylic cations with isothiocyanates is developed. The aza-oxyallyic cations were generated in situ in the present of a base. This cycloaddition reaction allows the rapid access to a variety of thiazolidin-4-one derivatives in mild conditions, good yield, and excellent functional group compatibility. |
| Keywords: | Cycloaddition Aza-oxyallylic cation One-pot Heterocycles Isothiocyanates |
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