Development of CN Coupling Using Mechanochemistry: Catalytic Coupling of Arylsulfonamides and Carbodiimides |
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| Authors: | Davin Tan Cristina Mottillo Athanassios D. Katsenis Dr. Vjekoslav Štrukil Prof. Dr. Tomislav Friščić |
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| Affiliation: | 1. Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W. H3A 0B8 Montreal (Canada);2. Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens (Greece);3. Laboratory for Physical Organic Chemistry, Division of Organic Chemistry and Biochemistry, Ru?er Bo?kovi? Institute, Zagreb (Croatia) |
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| Abstract: | Reported herein is the mechanochemical synthesis of sulfonyl guanidines, a family of molecules which are relevant as pharmaceuticals and herbicides, by direct coupling of sulfonamides and aromatic or aliphatic carbodiimides. Attempts to conduct the coupling in solution have either failed or given very low conversions, thus demonstrating mechanochemistry as the necessary component for the discovery of this synthetic strategy. |
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| Keywords: | C N coupling copper heterogeneous catalysis mechanosynthesis synthetic methods |
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