Plasmonic Liquid Marbles: A Miniature Substrate‐less SERS Platform for Quantitative and Multiplex Ultratrace Molecular Detection |
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| Authors: | Hiang Kwee Lee Dr. Yih Hong Lee Dr. In Yee Phang Jiaqi Wei Yue‐E Miao Prof. Tianxi Liu Prof. Xing Yi Ling |
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| Affiliation: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 50 Nanyang Ave, Singapore 637371 (Singapore);2. Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602 (Singapore);3. State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433 (P.R. China) |
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| Abstract: | Inspired by aphids, liquid marbles have been studied extensively and have found application as isolated microreactors, as micropumps, and in sensing. However, current liquid‐marble‐based sensing methodologies are limited to qualitative colorimetry‐based detection. Herein we describe the fabrication of a plasmonic liquid marble as a substrate‐less analytical platform which, when coupled with ultrasensitive SERS, enables simultaneous multiplex quantification and the identification of ultratrace analytes across separate phases. Our plasmonic liquid marble demonstrates excellent mechanical stability and is suitable for the quantitative examination of ultratrace analytes, with detection limits as low as 0.3 fmol, which corresponds to an analytical enhancement factor of 5×108. The results of our simultaneous detection scheme based on plasmonic liquid marbles and an aqueous–solid–organic interface quantitatively tally with those found for the individual detection of methylene blue and coumarin. |
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| Keywords: | liquid marbles multiplex detection sensors surface‐enhanced Raman spectroscopy ultratrace detection |
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