Improvement of Dispersion and Release Properties of Nifedipine in Suppositories
by Complexation with 2-Hydroxypropyl-β-cyclodextrin |
| |
| Authors: | Katsunori Nishimura Rie Hidaka Fumitoshi Hirayama Hidetoshi Arima Kaneto Uekama |
| |
| Institution: | (1) Deutsches Textilforschungszentrum Nord-West e.V., Adlerstr. 1, D-47798 Krefeld, Germany;(2) Department of Applied Natural Sciences, University of Applied Sciences Gelsenkirchen, August-Schmidt-Ring 10, D-45665 Recklinghausen, Germany |
| |
| Abstract: | Geometries, electronic properties and NMR-shielding of cucurbit5]uril, decamethylcucurbit5]uril, cucurbit6]uril, cucurbit7]uril,
and cucurbit8]uril are investigated with DFT calculations. All molecules are highly symmetrical with a distinct geometric
flexibility. In addition with a characteristic partial charge distribution these findings account for their chemical complex
building ability. |
| |
| Keywords: | B3LYP cucurbituril cucurbit[5]uril cucurbit[6]uril cucurbit[7]uril cucurbit[8]uril decamethylcucurbit [5]uril DFT GIAO NMR |
| 本文献已被 SpringerLink 等数据库收录！ |
|
