Revision of the stereochemistry of the reductive Heck cyclisation of 1-(2-iodobenzoyl)-4-substituted-1.4-dihydro-pyridine-3-carbaldehyde aminals |
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Authors: | Pierre Mangeney Christophe Pays |
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Institution: | Laboratoire de Chimie Organique, UMR 7611 Université P. et M. Curie, 4 place Jussieu, F-75252 Paris cedex 05, France |
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Abstract: | The stereochemistry of reductive and non reductive Heck cyclisations of 4-substituted-1.4-dihydropyridines is reexamined. The both reactions occur mainly via an anti (from the C4 substituent) 5-exo process without any epimerisation of the C4-H. |
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Keywords: | dihydropyridines chiral aminals Heck reactions isondolone synthesis |
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