Optimization of spiroimidazolidinone derivatives synthesis on solid phase using SynPhase™ Lanterns |
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| Authors: | Philippe BedosLidia Feliu Jean MartinezMuriel Amblard |
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| Institution: | Laboratoire des Amino acides Peptides et Protéines-UMR-CNRS 5810-15, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cédex 5, France |
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| Abstract: | We report the synthesis of 1,4,8-triazaspiro4.5]decan-2-one derivatives from N-benzyl-4-piperidone and N-protected amino acid amides on solid support. We have translated the chemistry from solution to solid phase using a backbone amide linker (BAL) mimic. Using a parallel combinatorial approach, we performed the optimization of the synthesis on SynPhase™ Lanterns. |
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| Keywords: | spiroimidazolidinone SynPhase&trade Lanterns backbone amide linker mimic optimization |
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