A general method for C3 reductive alkylation of indoles |
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Authors: | Anu MahadevanMario Gonzalez John C McKew |
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Institution: | a Organix Incorporated 240 Salem Street, Woburn, MA 01801, USA b Wyeth Research, Department of Chemical and Screening Sciences, 200 Cambridge Park Drive, Cambridge, MA 02140, USA |
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Abstract: | General indole C3 reductive alkylation conditions have been developed. The scope of this reaction includes C2 unsubstituted indoles, aryl and alkyl aldehydes, as well as N-H and N-alkyl indole substrates. |
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