A divergent approach to apoptolidin and FD-891: asymmetric preparation of a common intermediate期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A divergent approach to apoptolidin and FD-891: asymmetric preparation of a common intermediate

Authors:	Shu-Sin ChngJia Xu Teck-Peng Loh

Affiliation:	Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543

Abstract:	Biologically active Apoptolidin and FD-891 have structural similarity in their macrocyclic cores. Asymmetric preparation of a common intermediate in the total synthesis of these two macrolides is presented. A modified Masuyama Sn-allylation was employed to control the relative stereochemistry in the synthesis of the intermediate.

Keywords:	apoptolidin FD-891 divergent synthesis
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