Practical, efficient, stereoselective, formal synthesis of (2R,3R,4R)-3-hydroxy-4-methylproline |
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| Authors: | Sadagopan Raghavan S Ramakrishna Reddy |
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| Institution: | Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A highly efficient and stereoselective synthesis of (2R,3R,4R)-HMP is disclosed employing the sulfinyl group as an internal nucleophile to functionalize an olefin in the key step of the reaction sequence. The proline ring is elaborated by a (4C+N) cyclization. |
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| Keywords: | sulfoxide hydroxymethyl proline bromohydrin stereoselective |
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