Synthesis of β-phenyl-δ,ε-unsaturated amino acids and stereoselective introduction of side chain groups into [4,3,0]-bicyclic β-turn dipeptides |
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Authors: | Xuyuan GuScott Cowell Jinfa YingXuejun Tang Victor J Hruby |
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Institution: | Department of Chemistry, 1306 E. University, Tucson, AZ 85721, USA |
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Abstract: | (2S,3S)- and (2R,3R)-2-amino-3-phenyl-5-hexenoic acids have been synthesized in large scale by using Ni(II)-complexes as a template. The amino acids were used in the synthesis of 4,3,0]-bicyclic β-turn mimetics by a convergent methodology. The unique advantage of this strategy is the convenience of introducing side chain groups with predetermined chiralities on both the five- and six-membered heterocyclic rings. |
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Keywords: | Ni(II)-complex δ ε-unsaturated amino acid β-side chain β-turn mimetic bicyclic dipeptide |
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