A facile zirconium(IV) chloride catalysed selective deprotection of t-butyldimethylsilyl (TBDMS) ethers |
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| Authors: | GVM Sharma B SrinivasPalakodety Radha Krishna |
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| Institution: | D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A simple and efficient protocol for the selective deprotection of t-butyldimethylsilyl (TBDMS) ethers using 20 mol% ZrCl4 in 20-45 min and in high yields, is reported, wherein it is demonstrated that acid and base sensitive groups and allylic and benzylic groups are unaffected. |
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| Keywords: | TBDMS ethers zirconium(IV) chloride desilylation protecting groups |
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