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Synthesis of 2-acylindole-3-acetic acids: a novel base-mediated indole synthesis |
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| Authors: | Kazunari NakaoYoshinori Murata Hiroki KoikeChikara Uchida Kiyoshi KawamuraSachiko Mihara Shigeo HayashiRodney W. Stevens |
| Affiliation: | Discovery Chemistry Research, Nagoya Laboratories, Global Research & Development, Pfizer Inc., 5-2 Taketoyo, Aichi 470-2393, Japan |
| Abstract: | An efficient and expedient synthetic route to 2-acylindole-3-acetic acids is described. This work first demonstrates a one-pot room-temperature indole ring construction via the in situ generation of indoline intermediate. |
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