A convenient synthesis of trisubstituted pyrido[2,3-d]pyrimidin-7-ones |
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| Authors: | Jiri KasparecJerry L. Adams Joseph SiskoDomingos J. Silva |
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| Affiliation: | a Medicinal Chemistry Department, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA
b Synthetic Chemistry Department, GlaxoSmithKline, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA |
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| Abstract: | A novel, highly efficient and scalable route for the synthesis of trisubstituted pyrido[2,3-d]pyrimidin-7-ones was developed. The target compounds were synthesized in five steps from readily available reagents in about 40% overall yield. |
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