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Aluminium(III) as a promoter of cellular oxidation |
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| Authors: | Paolo Zatta Tamas KissMario Suwalsky Guy Berthon |
| Institution: | a Department of Biology, University of Padova, CNR Center on Metalloproteins, Viale G. Colombo 3, 35121 Padova, Italy b Department of Inorganic, Metallorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary c Faculty of Chemical Sciences, University of Concepcion, Casilla 160-C, Concepcion, Chile d Équipe de Chimie Bioinorganique Médicale, ICMPS-CNRS FR1744, Université Paul Sabatier, Toulouse, France |
| Abstract: | Aluminium has been known as a neurotoxic agent to experimental animals since the last century (Arch. Exp. Pharmacol. 40 (1897) 98). However, great interest arose in it bioinorganic chemistry as well biology when it was demonstrated to be the causative agent in pathologies related to the long-term dialysis treatment of uremic subjects with renal failure (Life Chem. 11 (1994) 197), and as a potential etiopathogenic cofactor for several neurodegenerative diseases. The inorganic biochemistry of aluminium is still largely to be discovered. In this review the pro-oxidative property of aluminium toward biological membrane will be presented and its implications in involvement in human pathology will be discussed in an interdisciplinary frame from the bioinorganic point of view. |
| Keywords: | Aluminium Free radicals Metal ions Neurodegeneration Plasma membrane Lipid peroxidation Antioxidative enzyme Alzheimer's disease |
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