Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate |
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| Authors: | Tuncel Sinem Fournier-dit-Chabert Jérémie Albrieux Florian Ahsen Vefa Ducki Sylvie Dumoulin Fabienne |
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| Affiliation: | Department of Chemistry, Gebze Institute of Technology, P.O. Box 141, 41400 Gebze Kocaeli, Turkey. ahsen@gyte.edu.tr fdumoulin@gyte.edu.tr. |
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| Abstract: | ![]()
A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(ii) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized. |
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