Palladium-catalyzed C-H perfluoroalkylation of arenes |
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| Authors: | Loy Rebecca N Sanford Melanie S |
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| Affiliation: | Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States. |
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| Abstract: | A new Pd-catalyzed reaction for the coupling between perfluoroalkyl iodides (R(F)I) and simple aromatic substrates is described. The perfluoroalkylated arene products are obtained in good to excellent yields in the presence of a phosphine-ligated Pd catalyst and Cs(2)CO(3) as a base. The development, optimization, scope, and preliminary mechanistic studies of these transformations are reported. |
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