Chromatographic evaluation of some stationary phases based on poly(methyloctylsiloxane) immobilized onto silica |
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Authors: | Endler M Borges |
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Institution: | Institute of Chemistry, University of Campinas, P.O. Box 6154, 13083-970, Campinas, SP, Brazil |
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Abstract: | Several stationary phases were prepared by thermal immobilization of poly(methyloctylsiloxane) onto a silica surface using different amounts of poly(methyloctylsiloaxane), and different times and temperatures of immobilization to provide different carbon contents for the phases. The chromatographic properties were evaluated using the Tanaka test. Comparison of the results obtained with literature data using hierarchical cluster analysis showed dissimilarity with most of the commercial phases. Some basic pharmaceuticals, including six benzodiazepines were separated on one of the better PMOS phases. |
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Keywords: | Stationary phase Poly(methyloctylsiloxane) Hierarchical cluster analysis Tanaka test HPLC |
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