Enantioselective synthesis of P-stereogenic benzophospholanes via palladium-catalyzed intramolecular cyclization |
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| Authors: | Brunker Tim J Anderson Brian J Blank Natalia F Glueck David S Rheingold Arnold L |
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| Affiliation: | 6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA. |
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| Abstract: | Enantioselective or diastereoselective intramolecular cyclization of functionalized secondary phosphines or their borane adducts catalyzed by chiral Pd(diphosphine) complexes gave P-stereogenic benzophospholanes in up to 70% ee. These results provide a new method for the synthesis of chiral phospholanes, which are valuable ligands in asymmetric catalysis. [reaction: see text] |
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