| 两种水溶性卟啉与DNA相互作用的研究 |
| |
| 引用本文： | 熊亚,黄素秋,吴鼎泉,屈松生.两种水溶性卟啉与DNA相互作用的研究[J].物理化学学报,1996,12(6):543-546. |
| |
| 作者姓名： | 熊亚 黄素秋 吴鼎泉 屈松生 |
| |
| 作者单位： | Department of Chemistry,Wuhan University,Wuhan 430072 |
| |
| 基金项目： | 国家自然科学基金，高等学校博士点专项基金 |
| |
| 摘 要： | 卟啉化合物以其对肿瘤组织的特殊亲和性和光动力学效应受到广泛的重视，国内外这方面的研究报导甚多．自1979年Fief等人1]证实水溶性四-（4-甲基吡啶基）卟啉及其金属配合物能嵌入DNA的碱基之后，人们以这类水溶性卟啉为模型化合物，利用各种物理和化学手段研究它们与DNA和RNA
|
| 关 键 词： | 卟啉 DNA 微量热法 紫外光谱 相互作用 |
| 收稿时间： | 1995-09-13 |
| 修稿时间： | 1995-12-14 |
Studies on the Interactions of Two Kinds of Water-Soluble Porphyrins with DNA |
| |
| Xiong Ya ,Huang Suqiu, Wu Dingquang ,Qu Songsheng.Studies on the Interactions of Two Kinds of Water-Soluble Porphyrins with DNA[J].Acta Physico-Chimica Sinica,1996,12(6):543-546. |
| |
| Authors: | Xiong Ya Huang Suqiu Wu Dingquang Qu Songsheng |
| |
| Institution: | Department of Chemistry,Wuhan University,Wuhan 430072 |
| |
| Abstract: | The interactions of two kinds of water-soluble porphyrins, Cu (NEAE) and H2PPS, with DNA have been investigated by microcalorimetry and UV spectroscopy. The experimental results show that Cu (NEAE) interact with dsDNA in the outside-bound mode, its binding number is 9～10 base pairs and its binding enthalpy △H＝-24.4kJ．mol-1. There are large enthalpy changes when Cu (NEAE) react with ssDNA. H2PPS can not react with both dsDNA and ssDAN, which demonstrats that the coulombic force is one of the important factors affecting the interactions of porphyrins with DNA. |
| |
| Keywords: | Porphyrin DNA Microcalorimetry UV spectroscopy Interaction |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《物理化学学报》浏览原始摘要信息 |
| 点击此处可从《物理化学学报》下载免费的PDF全文 |
|
