| 一株红树内生真菌Penicillium sp.(ZZF29#)次级代谢产物分离与鉴定 |
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| 引用本文： | 李尚德,魏美燕,李志华,佘志刚,林永成.一株红树内生真菌Penicillium sp.(ZZF29#)次级代谢产物分离与鉴定[J].应用化学,2012,29(6):727-729. |
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| 作者姓名： | 李尚德 魏美燕 李志华 佘志刚 林永成 |
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| 作者单位： | (1.广东医学院药学院 东莞 523808；2.中山大学化学与化学工程学院 广州 510275) |
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| 基金项目： | 湛江市科技攻关计划项目，广东医学院面上基金资助项目 |
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| 摘 要： | 研究了一株药用红树内生真菌Penicillium sp.(ZZF29#)的次级代谢产物。用硅胶柱层析、制备薄层层析和重结晶等方法,从该菌发酵液的乙酸乙酯相中分离获得8种单体化合物,运用现代波谱技术并与文献数据对照,鉴定其结构分别为:环(苯丙-丙)二肽(1)、环(苯丙-甘)二肽(2)、环(苯丙-苯丙)二肽(3)、环(苯丙-酪)二肽(4)、大黄素(5)、大黄素甲醚(6)、麦角甾醇(7)和过氧化麦角甾醇(8)。
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| 关 键 词： | 红树内生真菌 次级代谢产物 环二肽 蒽醌 甾醇 |
| 收稿时间： | 2011-09-28 |
Isolation and Structure Elucidation of Secondary Metabolites from Mangrove Endophytic Fungus Penicillium sp.(ZZF29#) |
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| LI Shangde
,
WEI Meiyan
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LI Zhihua
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SHE Zhigang
,
LIN Yongcheng.Isolation and Structure Elucidation of Secondary Metabolites from Mangrove Endophytic Fungus Penicillium sp.(ZZF29#)[J].Chinese Journal of Applied Chemistry,2012,29(6):727-729. |
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| Authors: | LI Shangde WEI Meiyan LI Zhihua SHE Zhigang LIN Yongcheng |
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| Institution: | (1.School of Pharmacy,Guangdong Medical College,Dongguan 523808,China;
2.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China) |
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| Abstract: | The secondary metabolites of the medicinal mangrove endophytic fungus Penicillium sp.(ZZF29#) were firstly studied.Eight compounds were isolated from the ethyl acetate extract of the fermentation using silica gel column chromatography,preparative thin-layer chromatography and recrystallization.The structures of the compounds were identified as cyclo-(Phe-Ala)(1),cyclo-(Phe-Gly)(2),cyclo-(Phe-Phe)(3),cyclo-(Phe-Tyr)(4),emodin(5),physcion(6),ergosterol(7) and peroxide ergosterol(8),by comprehensive spectroscopic characterizations as well as comparison with reported data. |
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| Keywords: | mangrove endophytic fungus Penicillium sp (ZZF29#) secondary metabolites isolation and elucidation cyclodipeptides anthraquinones sterols |
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