Dictyostelium cells bind a secreted autocrine factor that represses cell proliferation |
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| Authors: | Jonathan M Choe Deenadayalan Bakthavatsalam Jonathan E Phillips Richard H Gomer |
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| Institution: | (1) Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Road, Beaverton, Oregon 97006, USA;(2) Institute of Microbial Technology, CSIR, Sector-39A, 160036 Chandigarh, India;(3) Informatics, GVK Biosciences, 500037 Hyderabad, India |
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| Abstract: | Background
Mycobacterium tuberculosis, an intracellular pathogen encounters redox stress throughout its life inside the host. In order to protect itself from the
redox onslaughts of host immune system, M. tuberculosis appears to have developed accessory thioredoxin-like proteins which are represented by ORFs encoding WhiB-like proteins.
We have earlier reported that WhiB1/Rv3219 is a thioredoxin like protein of M. tuberculosis and functions as a protein disulfide reductase. Generally thioredoxins have many substrate proteins. The current study aims
to identify the substrate protein(s) of M. tuberculosis WhiB1. |
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