Etude de la reactivite des coumarines—I : Regioselectivete des reactifs de grignard engages avec la coumarine |
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| Authors: | M. Abou-Assali C. Decoret J. Royer J. Dreux |
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| Affiliation: | Université Claude Bernard Lyon I, Département de Chimie Organique, E.S.C.I.L., 43 Boulevard du 11 Novembre 1918, 69621 Villeurbanne, France |
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| Abstract: | The various products obtained by the action of organomagnesium, compounds on coumarin result from 1.2-1.2 di-addition (phenolic alcohols) or 1.2–1.4 di-addition (ketophenols) or 1.4 mono-addition (dihydrobenzopyrones). The results show the importance of the nature of the halogen component of the Grignard reagent. A theoretical model allows regioselectivity of coumarine in relation to the group R and the halogene X to be evaluated. |
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