Mamanine and pohakuline,two unprecedented quinolizidine alkaloids from sophorachrysophylla |
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| Authors: | Mavis M. Kadooka Mildred Y. Chang Hiroshi Fukami P.J. Scheuer Jon Clardy Barbara A. Solheim James P. Springer |
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| Affiliation: | Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, U.S.A.;Ames Laboratory-USERDA and Department of Chemistry, Iowa State University, Ames, IO 50010, U.S.A. |
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| Abstract: | ![]()
From the bark of the endemic Hawaiian tree Sophora chrysophylla Seem. we have isolated two unprecedented quainolizidine alkaloids, mamanine (4) and pohakuline (5). Both bases are 1-hydroxymethylenequinolizidines which are linked at C-3 to α-pyridone or α-piperidone moieties. The alkaloids may be intermediates in a heretofore unknown biogenetic pathway of Sophora alkaloids. |
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