A convenient,rapid microwave assisted synthesis of some novel 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles using acidic alumina |
| |
| Authors: | Jignesh P. Raval Hemul V. Patel Pradip S. Patel Kishor R. Desai |
| |
| Affiliation: | 1. Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar, 388 121 Anand, Gujarat, India;2. Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat 395 001, Gujarat, India |
| |
| Abstract: | A facile synthesis of 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 3a–n has been achieved by microwave promoted condensation of 3-mercapto-4-amino-5-[(4-chloro-3-methylphenoxy)methyl]-4H-1,2,4-triazole 1 with various aromatic aldehydes 2a–n in presence of catalytic amount of p-TsOH (para-toluenesulphonic acid). The structures of 3a–n are supported by IR and 1H and 13C NMR spectral data. |
| |
| Keywords: | Microwave Acidic alumina |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
